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. 2007 Oct 11;35(20):7041. doi: 10.1093/nar/gkm819

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© 2007 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Rearrangement on the secondary structure level induced by double methylation of human cytosolic tRNA^Asn. The calculated structure of the unmodified transcript on the left side features an aberrant D-stem without G10, but including G26. Double methylation on N6 of G26 impedes its Watson–Crick pairing with Cytidines and thus renders the base pair G26-C11, which is highlighted by a box, impossible. The fully modified tRNA^Asn may thus adopt the classical cloverleaf structure as shown on the right. U? denoted an unknown modified uridine, likely a derivative of ribothymidine, at position 54.