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. Author manuscript; available in PMC: 2009 Jan 18.
Published in final edited form as: Biochem Biophys Res Commun. 2007 Nov 9;365(3):446–452. doi: 10.1016/j.bbrc.2007.10.189

Fig. 3.

Fig. 3

Cholesterol levels and analysis of genes involved in cholesterol metabolism in wild type and ΔTrsp mice. (A) Examination of plasma cholesterol levels in wild type and ΔTrsp male and female mice. The values represent means ± SE, n = 5 mice/sex · genotype−1 (p < 0.01 for both genders). (B) Microarray analysis, using total RNA from liver of wild type and ΔTrsp mice showing genes with altered expression involved in cholesterol biosynthesis, metabolism or transport. Results from four independent hybridizations are shown in the column designated ΔFOLD wherein an arrow pointing up indicates a relative increase, and an arrow pointing down, a relative decrease in mRNA expression; and the standard error is shown in the column designated SE. (C) Real-time PCR analysis of mRNA levels of some of the genes tabulated in Fig. 3B. The results represent 3–4 independent experiments, each carried out in triplicate and shown along with the error bars (*, p < 0.005; **, p < 0.1)