Table 3.

Intra-individual variability in docetaxel pharmacokinetic parameters in patients treated with 20 mg/m² and 100 mg/m²

	Ratio cycle 2/cycle 1#
Variables	20 mg/m2		100 mg/m2
	Median	Range	Median	Range
Cmax	1.06	0.4–1.6	1.07	0.9–1.3
AUC0–25	1.12	0.6–1.5	1.13	0.9–1.5
AUC0–72	1.12	0.8–1.3	ND	ND
Clearance	0.90	0.8–1.7	0.89	0.8–1.1
t1/2α	0.94	0.4–1.1	1.15	1.1–1.5
t1/2β	0.95	0.7–1.5	1.15	0.7–1.4
t1/2γ	1.03	0.7–1.3	ND	ND
C72h	0.92	0.6–2.1	ND	ND
AAG	0.98	0.7–1.7	1.15	0.9–1.4

#: Each variable was calculated based on data from 4 to 10 patients.