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Inhibition of ligand-dependent receptor phosphorylation in viable cells
| Phosphorylation | IC50, nM
|
|
|---|---|---|
| PD 168393 | PD 174265 | |
| Purified EGFr TK | 0.70 ± 0.09 | 0.45 ± 0.06 |
| EGF-induced tyrosine phosphorylation in A431 cells | 4.3 ± 0.6 | 39 ± 12 |
| Heregulin-induced tyrosine phosphorylation in MDA-MB-453 cells | 5.7 ± 0.8 | 220 ± 65 |
IC50 values represent the concentration of compound that inhibits activity by 50% ± SE and are the mean of three separate experiments.
