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. 1998 Sep 29;95(20):12028–12033. doi: 10.1073/pnas.95.20.12028

Figure 4.

Figure 4

(a) Comparative antinociceptive properties of the most efficient dual inhibitors 7B to 9B and kelatorphan on the hot plate test in mice (55°C ± 0.5) (jump response) measured 15 min after ICV administration of the compounds. Each points represents the percentage of analgesia ± SEM (n = 10 mice). ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001 (Dunnett’s t test). (a) Comparative antinociceptive effects of compound 9B and kelatorphan in the writhing test in mice (n = 10 mice). The drugs were injected ICV at the doses indicated 15 min before testing. The results are expressed as percentage of analgesia ± SEM. ∗∗, P < 0.01; ∗∗∗, P < 0.001 (Dunnett’s t test).