TABLE 5.
Fatal cases of F. necrophorum and Lemierre's syndromea
| Author(s) (reference) | Patient age (yr) | Culture result | Site of entry | Lemierre's syndrome | Deep neck abscess or extension | Intracerebral complication(s) | Lung lesions | Other systemic metastases | Day of death (from admission) | Possible contributory factor(s) |
|---|---|---|---|---|---|---|---|---|---|---|
| Dhawan et al. (115) | 4 | F. necrophorum | Throat | Yes | Yes | Yes | 24 | DP, DIC | ||
| Garimella et al. (154) | 51 | F. necrophorum | Ear | Meningitis | 9 | Alcohol, MGT, BSI, ICP | ||||
| Garnham and Longstaff (155) | 30 | F. necrophorum | Throat | Yes | Yes | 2 | DRx, PI, SS | |||
| Golledge et al. (162) | 17 | F. necrophorum | Throat | Yes | Yes | 5 | DRx, DIC, MA | |||
| Goyal et al. (167) | 8 | F. necrophorum | Throat | Yes | Yes | ? | ||||
| Hirschel et al. (190) | 18 | F. necrophorum | Throat | Yes | Yes | 1 | SS, DIC | |||
| Ieven et al. (200) | 65 | F. necrophorum | Unclear | 5 | PI | |||||
| Islam and Shneerson (203) | 13 | F. necrophorum | Unclear | Meningitis, abscess | 1 | MGT, CI, BH | ||||
| Jacobs et al. (204) | 5 | F. necrophorum | Ear | Meningitis, abscess | 5 | MGT, ICP | ||||
| Larsen et al. (233) | 0.75 | F. necrophorum | Unclear | Meningitis, cerebral infarcts | 2 | MGT, CI, ICP | ||||
| Marangos et al. (261) | 20 | F. necrophorum | Throat | Yes | LPA | Cerebral edema with tonsillar herniation | Yes | 4 | ARDS, CI, ICP, BH | |
| Møller and Dreijer (274) | 43 | F. necrophorum | Throat | Mediastinitis | Yes | 8 | MS, SS | |||
| Møller and Dreijer (274) | 33 | Fusobacterium sp. | Throat | PTrA and RSA | Yes | 27 | DP, SS, RF, RSA | |||
| Mukau (280) | 63 | F. necrophorum | Throat | Yes | RPA and | Yes | 3 | PI, MS, PC | ||
| Potter et al. (308) | 23 | F. necrophorum | Throat | mediastinitis | <1 | SS, DIC | ||||
| Pulcini et al. (310) | 18 | Fusobacterium sp. | Throat | Yes | Yes | <1 | SRx, SS, RF | |||
| Seidenfield et al. (338) | 18 | F. necrophorum | Throat | Yes | PTA | Yes | 9 | OP | ||
| Veldhoen et al. (387) | 4 | F. necrophorum | Ear | Meningitis, ventriculitis, cerebral infarct | 2 | MGT, CI, DP | ||||
| Veldhoen et al. (387) | 5 | F. necrophorum | Ear | Meningitis, cerebral | Yes | 2 | MGT, ICP, CI | |||
| Venkatasawaran and Sze (390) | 36 | Fusobacterium sp. | Throat | Yes | infarcts | Yes | 8 | DP, DIC, RF, SS | ||
| Vohra et al. (392) | 21 | F. necrophorum | Throat | Yes | Cerebral abscess | Yes | Yes | 16 | DRx, ARDS |
a
Abbreviations: ARDS, adult respiratory distress syndrome; BH, brain herniation; BSI, brain stem infarct; CI, cerebral infarct; DIC, disseminated intravascular coagulation; DP, delayed presentation; DRx, delayed initiation of appropriate therapy; ICP, raised intracranial pressure; LPA, lateral pharyngeal abscess; MS, mediastinitis; MGT, meningitis, MA, myocardial abscess; OP, operative complication; PC, pericarditis; PI, previous illness; PTA, peritonsillar abscess; PTrA, paratracheal abscess; RF, acute renal failure; RPA, retropharyngeal abscess; RSA, retrosternal abscess; SRx, steroid therapy; SS, septic shock.