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. 2007 Oct 25;7:119. doi: 10.1186/1471-213X-7-119

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Copyright © 2007 Wroble et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Inhibition of Cdk2 triggers apoptosis. One-cell stage embryos were injected with 5 ng of Δ34-Xic1 or p27Xic1CK- (control) protein. (A) Embryos expressing Δ34-Xic1 were delayed approximately one cell cycle at Stage 8 (5 hr pf) compared to p27Xic1CK- controls. At Stage 11 (12 hr pf), embryos expressing Δ34-Xic1 exhibited abnormal morphology consistent with apoptosis compared to p27Xic1CK- controls, which gastrulated. p27Xic1CK- controls continued to develop through gastrulation and formed a neural groove, evident at Stage 13 (16 hr pf). (B) Extracts of Stage 11 embryos were incubated with recombinant PARP, a substrate for caspase 3 [4]. The presence of a cleaved PARP fragment indicates caspase activity. Replicate samples are shown.