Figure 2.

Illustration of VEGF's fulfillment of Koch's alveolarization postulate. (1) Inhibition of VEGF signaling impairs alveolarization; (2) conversely, impaired alveolarization in human and experimental BPD is associated with decreased VEGF signaling; (3) lung overexpression or activation of VEGF in experimental BPD restores normal alveolar development.