Figure 3.

The effects of treatment with protective antigen–directed monoclonal antibody (PA-mAb) compared with placebo started at the time of or up to 12 h after the start of a 24-h LeTx infusion on (A) mean arterial blood pressure (MBP) and (B) the hazard ratio of survival in rats. Blood pressures were measured and averaged over the 12 h after treatment, and survival was monitored for 168 h. PA-mAb increased blood pressure and survival either significantly or in trends approaching it even if delayed for up to 12 h after the start of LeTx (29).