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Six-minute-walk distance (A) is significantly lower in patients with sickle cell disease and pulmonary hypertension (PHT) compared with those without PHT, (B) is inversely correlated with tricuspid regurgitant jet velocity (n = 40), and (C) is inversely correlated with mean pulmonary artery pressure (mPAP) (n = 35). Six-minute-walk distance is directly correlated with (D) maximal oxygen consumption (V̇o2max) (n = 34).
