TABLE 1.
Without PHT | With PHT | p Value | |
---|---|---|---|
No. of patients | 17 | 26 | |
Age, yr | 41 ± 2.2 (27, 60) | 43 ± 2.1 (23, 62) | 0.39 |
Sex, M/F | 8/9 | 11/15 | |
Hb, g/dl | 8.1 ± 0.3 (4.7, 10) | 8.3 ± 0.2 (5.2, 11.0) | 0.60 |
Hb F, % | 6.8 ± 1.2 (0.7, 18.2) | 7.3 ± 1.2 (1.2, 21.8) | 0.78 |
TR jet, m/s | 2.4 ± 0.1 (2, 3) | 3.4 ± 0.1 (2.8, 4.2) | < 0.001 |
Right atrial area, cm2 | 21.5 ± 1.4 (13.1, 41.8) | 22.5 ± 1.1 (13, 35) | 0.57 |
Left atrial size, mm | 40.4 ± 1.6 (30, 56) | 43.4 ± 1.3 (31, 62) | 0.15 |
Ejection fraction | 65 ± 2.2 (47, 77) | 61 ± 1.8 (39, 77) | 0.16 |
RAP, mm Hg | 6.2 ± 0.5 (4, 9) | 10.7 ± 1.1 (4, 34) | 0.02 |
mPAP, mm Hg* | 21.1 ± 0.4 (19, 23) | 36.6 ± 1.5 (25, 51.7) | < 0.001 |
PCWP, mm Hg | 12.1 ± 0.6 (10, 14) | 16.6 ± 1 (7, 27) | 0.009 |
CO, L/min | 10.9 ± 0.6 (7.6, 13.7) | 8.6 ± 0.5 (4, 13) | 0.017 |
PVR, dyn · s · cm−5 | 68.3 ± 6.2 (43, 94) | 206.1 ± 22.8 (57.4, 421) | 0.001 |
TPR, dyn · s · cm−5 | 157 ± 10 (116, 231) | 370 ± 26 (192, 612) | < 0.001 |
Pulmonary capacitance, ml/mm Hg | 8.5 ± 0.8 (4.8, 13.5) | 4.3 ± 0.5 (1.6, 13.8) | < 0.001 |
Sv̇O2, % | 73 ± 1.5 (68, 84) | 66 ± 1.3 (47, 78) | 0.010 |
Definition of abbreviations: CO = cardiac output; Hb = hemoglobin; Hb F = fetal hemoglobin; M/F = male/female; mPAP = mean pulmonary artery pressure; PCWP = pulmonary capillary wedge pressure; PVR = pulmonary vascular resistance; RAP = right atrial pressure; Sv̇O2= mixed venous oxygen saturation; TPR = total pulmonary resistance; TR jet = tricuspid regurgitant jet velocity;
Data are presented as mean ± SEM (min, max).
All patients with TR jet ⩾ 2.5 m/second were catheterized (n = 35).