TABLE 1.
CHARACTERISTICS OF COHORT
| Variable | All Participants (n = 3,075) | Hospitalized for CAP (n = 272) | Never Hospitalized for CAP (n = 2,803) | P Value |
|---|---|---|---|---|
| Demographic characteristics | ||||
| Age, mean ± SD | 73.6 ± 2.9 | 73.9 ± 2.9 | 73.6 ± 2.9 | 0.1 |
| Sex, males, % (n) | 48.5 (1,491) | 53.7 (146) | 48 (1,345) | 0.07 |
| Race, blacks, % (n) | 41.7 (1,281) | 40.4 (110) | 41.8 (1,171) | 0.7 |
| Site, Memphis, % (n) | 50.3 (1,547) | 47.4 (129) | 50.6 (1,418) | 0.3 |
| Comorbid conditions | ||||
| Congestive heart failure, % (n) | 3.1 (95) | 7.0 (19) | 2.7 (76) | <0.0001 |
| Coronary heart disease, % (n) | 20.8 (625) | 30.4 (81) | 19.9 (554) | <0.0001 |
| Diabetes, % (n) | 15.3 (470) | 21.5 (58) | 14.7 (412) | 0.003 |
| Serum creatinine, mg/dl, mean ± SD | 1.1 ± 0.4 | 1.1 ± 0.6 | 1.05 ± 0.4 | 0.003 |
| Predicted FEV1, % (n) | <0.0001 | |||
| FEV1 > 80% | 70.7 (2,175) | 52.2 (142) | 72.5 (2,033) | |
| 80% > FEV1 > 50% | 19.2 (591) | 25 (68) | 14 (523) | |
| FEV1 < 50% | 10.1 (309) | 22.8 (62) | 4.6 (247) | |
| Smoking, % (n) | <0.0001 | |||
| Current | 10.4 (318) | 16.9 (46) | 9.7 (272) | |
| Past | 45.7 (1,404) | 48.9 (133) | 45.4 (1,271) | |
| Pack-years of smoking, mean ± SD | 19.1 ± 28 | 27.4 ± 34 | 18.3 ± 28 | <0.0001 |
| Inflammatory markers, pg/ml, median (IQR) | ||||
| TNF | 3.2 (2.4–4.1) | 3.6 (0.9–16.8) | 3.1 (0.6–29.6) | <0.0001 |
| IL-6 | 1.8 (1.3–2.8) | 2.3 (0.3–13.2) | 1.8 (0.2–16) | <0.0001 |
| PAI-1 | 21 (13–36) | 24 (14–43) | 21 (12–36) | 0.02 |
Definition of abbreviations: CAP = community-acquired pneumonia; IQR = interquartile range; PAI-1 = plasminogen activator inhibitor-1; TNF = tumor necrosis factor.
Fewer than 5% of data are missing for some of the covariates.