TABLE 5.
ASSOCIATION BETWEEN GENOTYPE AND PHENOTYPE (PAI-1 AND COMMUNITY-ACQUIRED PNEUMONIA)
| Whites (n = 1,794)
|
Blacks (n = 1281)
|
|||||
|---|---|---|---|---|---|---|
| SNP | Genotype Frequency % (n) | PAI-1 Concentrations* | Frequency of CAP % (n) | Genotype Frequency % (n) | PAI-1 Concentrations* | Frequency of CAP % (n) |
| PAI4G,5G | ||||||
| 5G/5G | 21.8 (380) | 20 (11–31) | 5.3 (20) | 8.5 (104) | 20 (11–34) | 8.5 (9) |
| 5G/4G | 48.6 (846) | 22 (13–37) | 10.1 (85) | 39 (477) | 21 (13–37) | 8.8 (42) |
| 4G/4G | 29.6 (515) | 23 (13–43) | 9.7 (50) | 52.5 (642) | 23 (13–42) | 8.6 (55) |
| P value† | — | 0.0001 | 0.018 (0.049) | — | 0.0001 | 0.99 (0.99) |
| PAI2846 | ||||||
| A/A | 1.4 (25) | 22.5 (13–39) | 0 (0) | 0.1 (1) | 11 | 0 (0) |
| A/G | 20.4 (355) | 20 (12-32.5) | 5.6 (20) | 4.1 (51) | 24 (15–39) | 15.7 (8) |
| G/G | 78.2 (1,359) | 30 (14–44) | 9.9 (135) | 95.8 (1,179) | 21 (12–36) | 8.3 (98) |
| P value† | — | 0.03 | 0.012 (0.049) | — | 0.4 | 0.176 (0.617) |
| PAI2852 | ||||||
| A/A | 0.1 (2) | 15 | 50.0 (1) | 0.4 (5) | 15 (7–39) | 20 (1) |
| A/G | 2.7 (47) | 20 (13–30) | 8.5 (4) | 11.4 (140) | 19 (11–32) | 9.3 (13) |
| G/G | 97.2 (1,692) | 22 (13–38) | 8.8 (149) | 88.2 (1,084) | 21 (13–36) | 8.4 (91) |
| P value† | — | 0.40 | 0.122 (0.171) | — | 0.20 | 0.616 (0.99) |
| PAI4588 | ||||||
| C/C | 76 (1,224) | 21 (13–37) | 8.5 (104) | 76.8 (883) | 21 (12–36) | 9.3 (82) |
| C/T | 22 (353) | 22 (12–39) | 9.1 (32) | 20.8 (239) | 22 (12–36) | 8.4 (20) |
| T/T | 2 (31) | 18 (10–25) | 6.5 (2) | 2.4 (28) | 19 (12.5–35.5) | 7.1 (2) |
| P value† | — | 0.10 | 0.863 (0.863) | — | 0.80 | 0.853 (0.99) |
| PAI7343 | ||||||
| A/A | 62.4 (1,069) | 22 (13–41) | 10.5 (112) | 52.2 (629) | 20 (12–36) | 9.1 (57) |
| A/G | 32.8 (561) | 20 (12–32) | 6.4 (36) | 41.6 (501) | 21.5 (12.5–34.5) | 8 (40) |
| G/G | 4.8 (83) | 23 (14–35) | 7.2 (6) | 6.2 (74) | 22 (13–42.5) | 10.8 (8) |
| P value† | — | 0.03 | 0.021 (0.049) | — | 0.70 | 0.657 (0.99) |
| PAI12219 | ||||||
| C/C | 19.8 (339) | 22 (13–43) | 8.3 (28) | 24.4 (293) | 21 (12–36) | 9.6 (28) |
| C/T | 8.9 (835) | 23 (13–38) | 10.2 (85) | 46.9 (562) | 21 (12–35) | 8 (45) |
| T/T | 31.3 (535) | 20 (11–13) | 6.9 (37) | 28.7 (344) | 21 (13–37) | 9 (31) |
| P value† | — | 0.004 | 0.106 (0.171) | — | 0.78 | 0.721 (0.990) |
| PAI12750 | ||||||
| A/A | 4.5 (75) | 14.5 (9–26) | 10.7 (8) | 0.3 | 56 (17.5–111.5) | 50 (2) |
| A/G | 31.4 (521) | 23 (14–39) | 9.4 (49) | 8.4 | 27 (16–47) | 6.1 (6) |
| G/G | 64.1 (1,062) | 21 (13–37) | 8.6 (91) | 91.3 | 21 (12–35) | 9.5 (97) |
| P value† | — | 0.0004 | 0.743 (0.863) | — | 0.003 | 0.009 (0.066) |
Definition of abbreviations: CAP = community-acquired pneumonia; PAI-1 = plasminogen activator inhibitor-1; SNP = single nucleotide polymorphism.
Genotype data were missing for some patients.
*
Median PAI-1 concentrations (with interquartile range) in ng/ml.
†
P values adjusted for false-discovery rate are presented in parenthesis.