TABLE 6.
ASSOCIATION BETWEEN GENOTYPE AND PHENOTYPE (PAI-1 AND COMMUNITY-ACQUIRED PNEUMONIA) IN WHITES STRATIFIED BY SITE
| Memphis (n = 935)
|
Pittsburgh (n = 859)
|
||||||
|---|---|---|---|---|---|---|---|
| Locus | Genotypes | Risk (%) for CAP | P Value | PAI-1 Concentration (ng/ml) | Risk (%) for CAP | P Value | PAI-1 Concentration (ng/ml) |
| 4G,5G | 4G,4G 4G,5G | 10.5 | 0.0006 | 19 | 9.2* | 0.6 | 26 |
| 5G,5G | 2.6 | 16 | 7.9 | 23 | |||
| 2846 | AA AG | 5.9 | 0.11 | 17 | 4.4 | 0.015 | 23 |
| GG | 9.6 | 19 | 10.3 | 26 | |||
| 2852 | AA AG | 0 | 0.18 | 13.5 | 16.1 | 0.17 | 22 |
| GG | 8.8 | 19 | 8.8 | 25 | |||
| 4588 | TT CT | 8.8 | 0.72 | 16 | 9.9 | 0.48 | 26 |
| CC | 8 | 19 | 8.2 | 25 | |||
| 7343 | GG AG | 6.6 | 0.09 | 17 | 6.4 | 0.026 | 23 |
| AA | 10 | 19 | 11 | 26 | |||
| 12219 | CC CT | 10.3 | 0.004 | 20 | 9* | 0.76 | 26 |
| TT | 4.6 | 17 | 9.6 | 23 | |||
| 12750 | AA AG | 8.8 | 0.93 | 20.5 | 10.4 | 0.38 | 25 |
| GG | 8.6 | 17 | 8.5 | 25 | |||
Definition of abbreviations: CAP = community-acquired pneumonia; PAI-1 = plasminogen activator inhibitor-1.
*
Interaction P < 0.05 between genotype and site for CAP susceptibility.