TABLE 7.
ASSOCIATION BETWEEN COMMUNITY-ACQUIRED PNEUMONIA REQUIRING HOSPITALIZATION AND HAPLOTYPES BASED ON FOUR POLYMORPHISMS AMONG WHITE AND THREE POLYMORPHISMS AMONG BLACK PARTICIPANTS
| Haplotypes
|
Frequency of Haplotypes
|
|||||||
|---|---|---|---|---|---|---|---|---|
| PAI4G,5G | PAI2846 | PAI4588 | PAI7343 | PAI12750 | Overall | CAP Participants | Participants without CAP | P Value |
| Whites* | ||||||||
| 5G | A | C | G | 10.7 | 6.5 | 11.2 | 0.01 | |
| 5G | G | C | A | 18.9 | 19.0 | 18.9 | 0.93 | |
| 5G | G | C | G | 9.7 | 9.2 | 9.7 | 0.77 | |
| 5G | G | T | A | 6.3 | 6.2 | 6.3 | 0.99 | |
| 4G | G | C | A | 46.4 | 53.4 | 45.7 | 0.004 | |
| 4G | G | T | A | 6.6 | 5.2 | 6.7 | 0.40 | |
| Blacks† | ||||||||
| 5G | G | G | 65.8 | 64.0 | 65.9 | 0.59 | ||
| 4G | G | G | 27.5 | 27.6 | 27.4 | 0.93 | ||
Definition of abbreviation: CAP = community-acquired pneumonia.
A total of 1,562 participants had genotype data for the four single nucleotide polymorphisms in whites and 1,116 participants had genotype data for the three single nucleotide polymorphisms in blacks.
*
Exact P value for marker trait association was 0.01.
†
Exact P value for marker trait association was 0.33.