TABLE 3.
ASSOCIATIONS BETWEEN TRANSFORMING GROWTH FACTOR-β1 C-509T AND rs4803457 POLYMORPHISMS AND RS4803457T/−509T DIPLOTYPES AND ASTHMA
| Lifetime Asthma
|
Early Persistent Asthma*
|
Late-Onset Asthma†
|
|||||
|---|---|---|---|---|---|---|---|
| No Asthma (n) | n | OR (95% CI) | n | OR (95% CI) | n | OR (95% CI) | |
| rs1800469 (C-509T) | |||||||
| CC | 1,065 | 168 | 1.0 (Ref.) | 65 | 1.0 | 103 | 1.0 (Ref.) |
| CT | 1,211 | 184 | 0.98 (0.77–1.26) | 74 | 1.01 (0.70–1.47) | 110 | 0.94 (0.69–1.27) |
| TT | 339 | 56 | 1.33 (0.93–1.91) | 31 | 1.81 (1.11–2.95) | 25 | 0.95 (0.59–1.55) |
| rs4803457 (C>T) | |||||||
| CC | 861 | 141 | 1.0 (Ref.) | 55 | 1.0 (Ref.) | 86 | 1.0 (Ref.) |
| CT | 1,267 | 182 | 0.83 (0.64–1.08) | 73 | 0.79 (0.54–1.18) | 109 | 0.80 (0.58–1.10) |
| TT | 487 | 85 | 1.21 (0.88–1.67) | 42 | 1.46 (0.92–2.30) | 43 | 0.99 (0.66–1.49) |
| No. of rs4803457T/−509T diplotypes | |||||||
| 0 | 1.0 (Ref.) | 1.0 (Ref.) | 1.0 (Ref.) | ||||
| 1 | 0.98 (0.76–1.25) | 1.01 (0.69–1.46) | 0.94 (0.69–1.27) | ||||
| 2 | 1.35 (0.94–1.93) | 1.83 (1.12–2.98) | 0.97 (0.60–1.58) | ||||
Definition of abbreviations: CI = confidence interval; Ref. = reference category; OR = odds ratio.
*
Diagnosis by 3 years of age.
†
Diagnosis by 3 years of age.