TABLE 3.
BASELINE PULMONARY AND COMPUTED TOMOGRAPHIC FEATURES
| All Subjects | BAL+ | BAL− | P Value* | |||||
|---|---|---|---|---|---|---|---|---|
| Pulmonary Features | ||||||||
| No. of subjects | 141 | 101 | 40 | |||||
| Baseline dyspnea index (0–12) | 5.7 ± 1.7 | 5.7 ± 1.7 | 5.6 ± 1.7 | 0.7564 | ||||
| Cough index (0–4)† | 1.6 ± 0.6 | 1.7 ± 0.6 | 1.5 ± 0.5 | 0.1465 | ||||
| FVC, %predicted | 68.5 ± 11.9 | 66.7 ± 11.5 | 73.2 ± 11.6 | 0.0027 | ||||
| FEV1, %predicted | 69.3 ± 12.5 | 67.7 ± 12.7 | 73.4 ± 11.3 | 0.0149 | ||||
| TLC, %predicted | 69.7 ± 13.2 | 67.7 ± 13.2 | 74.6 ± 11.9 | 0.0053 | ||||
| DlCO, %predicted | 47.6 ± 14.3 | 45.5 ± 14.0 | 53.0 ± 13.8 | 0.0044 | ||||
| CT Findings | ||||||||
| Frequency of findings, n (%) | ||||||||
| Pure GGO | 68 (48) | 54 (53) | 14 (35) | 0.062 | ||||
| Fibrosis | 125 (89) | 93 (92) | 32 (80) | 0.073 | ||||
| Honeycombing | 53 (38) | 41 (41) | 12 (30) | 0.260 | ||||
| Total score | ||||||||
| Pure GGO | 7.16 ± 4.04 | 7.90 ± 3.94 | 5.26 ± 3.70 | 0.005 | ||||
| Fibrosis | 2.49 ± 3.04 | 2.70 ± 3.04 | 1.92 ± 3.01 | 0.180 | ||||
| Honeycombing | 1.43 ± 2.33 | 1.56 ± 2.40 | 1.08 ± 2.15 | 0.280 | ||||
| RML score | ||||||||
| Pure GGO | 0.42 ± 0.59 | 0.46 ± 0.60 | 0.32 ± 0.51 | 0.190 | ||||
| Fibrosis | 0.89 ± 0.65 | 0.99 ± 0.66 | 0.64 ± 0.58 | 0.0053 | ||||
| Honeycombing | 0.15 ± 0.32 | 0.17 ± 0.34 | 0.092 ± 0.26 | 0.210 | ||||
Definition of abbreviations: BAL = bronchoalveolar lavage; CT = computed tomography; GGO = ground-glass opacity; RML = right middle lobe.
Data are presented as mean ± SD. BAL+ cohort defined as having 3% or more of neutrophils and/or 2% or more of eosinophils; BAL− cohort defined as having less than 3% neutrophils and less than 2% eosinophils.
*
P value of comparison between patient subgroups using two-sample t test/Fisher's exact test.
†
Cough index graded on a 4-point Likert scale.