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Blockade of the type 1 TGF-β receptor does not increase plasminogen- or plasmin-mediated fibroblast apoptosis. (A) IMR-90 fibroblasts were treated with (A) plasmin (0.5 U/ml) or (B) plasminogen (50 μg/ml) in the presence/absence of the ALK-5 inhibitor SB431542 (1.0 μM). Apoptosis was assessed by ELISA for ssDNA after 18 hours. *P < 0.001 versus untreated controls (n = 4 per condition, and the experiment was repeated three times).
