TABLE 3.
PEDIGREE-BASED ASSOCIATION TEST FOR FEV1 (% PREDICTED) AND FEV1/FVC
| Gene | SNP | Minor Allele Frequency | FEV1 Pre-bd | FEV1 Post-bd | FEV1/FVC Pre-bd | FEV1/FVC Post-bd | Direction of Effect of Minor Allele on Lung Function Phenotypes |
|---|---|---|---|---|---|---|---|
| IL10 | rs1800871 (−819) | 0.25 | 0.0009 | 0.0005 | 0.003 | 0.0005 | Decrease |
| rs1518110 | 0.23 | 0.004 | 0.004 | 0.004 | 0.001 | Decrease | |
| rs1800896 (−1082) | 0.48 | 0.02 | 0.02 | > 0.05 | 0.05 | Increase | |
| rs1878672 | 0.48 | 0.02 | 0.02 | > 0.05 | > 0.05 | Increase | |
| rs3024496 | 0.48 | 0.02 | > 0.05 | > 0.05 | > 0.05 | Increase | |
| rs3024498 | 0.29 | 0.05 | > 0.05 | > 0.05 | > 0.05 | Increase | |
| TNF | rs1800610 | 0.07 | 0.02 | > 0.05 | > 0.05 | > 0.05 | Decrease |
| rs769178 | 0.07 | 0.01 | 0.04 | 0.05 | > 0.05 | Decrease | |
| rs3091257 | 0.11 | > 0.05 | > 0.05 | 0.05 | > 0.05 | Decrease | |
| SERPINE2 | rs12476888 | 0.41 | > 0.05 | 0.05 | > 0.05 | > 0.05 | Decrease |
| EPHX1 | rs2260863 | 0.29 | > 0.05 | > 0.05 | 0.009 | 0.02 | Decrease |
Definition of abbreviations: bd, bronchodilator; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; SNP, single-nucleotide polymorphism.
Exact P values by gene not presented if all SNPs for a gene have P > 0.05, and significant SNPs are presented in bold; each model was analyzed under the assumption of an additive mode of inheritance and adjusted for sex, ever-smoking, pack-years, pack-years2, and current smoking.