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. 2008 Feb 1;118(2):545–559. doi: 10.1172/JCI33145

Figure 3. MDP administration prevents DSS colitis.

Figure 3

NOD2-intact (NOD2+/+) and NOD2-deficient (NOD2–/–) mice were treated with drinking water containing 4% DSS for 6 days (days 0–5). At the early phase of colitis induction (days 0, 1, 2), mice were administered MDP (i.p.) or PBS every day. (A) Changes of body weight in PBS- or MDP-injected mice. *P < 0.05; **P < 0.01, time point values of NOD2-intact mice administered MDP compared with NOD2-intact mice administered PBS. (B) Serum amyloid A (SAA) levels and colitis scores of mice (see Methods) on day 7. SAA levels were determined by ELISA. *P < 0.05, NOD2-intact mice administered MDP compared with mice administered PBS.