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. 2008 Feb 1;118(2):695–709. doi: 10.1172/JCI33156

Figure 1. The combination of UDCA and dexamethasone upregulates AE2 alternative expression in NHCs.

Figure 1

The mRNA levels for AE2b1, AE2b2, and AE2a isoforms were determined by real-time PCR in cultured NHCs treated for 24 or 72 hours with either dexamethasone (DEX) and/or UDCA, GUDCA, TUDCA, CA, or CDCA (100 μM each) or with just vehicle. Values (normalized for GAPDH mRNA) are given as fold expression relative to values in the respective controls with just vehicle. Data are mean ± SD; n = 6 (except for GUDCA, TUDCA, CA, and CDCA — with and without DEX — for which n = 3 each). *P < 0.05, **P < 0.01, ***P < 0.001 versus vehicle control.