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Structures of NCp7 and RB 2121. (a) Sequence of HIV-1 Lai NCp7. The biological determinants (Phe-16, Arg-26, Arg-32, and Trp-37) used for designing NCp7 mimics are numbered. (b) Sequence of the cyclic hexapeptide mimic of NCp7, RB 2121. NCp7-targeted residues are in brackets. Hydrogen bonds evidenced by NMR are indicated by dotted lines. (c) RB 2121 and its analogues.
