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. 1999 Apr 27;96(9):4886–4891. doi: 10.1073/pnas.96.9.4886

Figure 7.

Figure 7

Importance of structural determinants for the retroviral activity of RB 2121. (a) Immobilized RT was preincubated or not with 43 μM RB 2121 or its analogues (lanes 3–8) for 1.5 h before the addition of 0.85 μM NCp7 in TBS-T buffer. Bound NCp7 was recovered and measured by Western blot analysis by using antibody selective of NCp7. Lane C+ corresponds to the total binding of NCp7 to immobilized RT, and lane C− corresponds to the same experiment with beads without RT. (b) Quantification of the inhibition of RT–NCp7 interaction by RB 2121 and its analogues. Data are expressed as the mean ± SD from three separate experiments.