. 2003 Sep;10(5):373–386. doi: 10.1101/lm.66103

Table 1.

Comparison of the Affinities of Various Compounds That Compete With the Binding of [³H]LSD to the Membranes of Cells Transfected With the 5-HT_ap1 and 5HT_ap2 cDNA

		K_i (nM)
Drug	Specificity	5-HT_ap1^a	5-HT_ap2^b
5-CT	5-HT₁ agonist	1.04	162
Methiothepin	Nonselective 5-HT antagonist	2.62	0.3
PAPP	5-HT_1A agonist/5-HT_1D antagonist	9.50	182
5-HT		13.23	241
Clozapine	5-HT₂ antagonist	56.63	2124
8-OH-DPAT	5-HT_1A-specific agonist	73.96	2089
Metergoline	5-HT_1-2-7 antagonist	90.66	36
Ketanserin	5-HT₂ antagonist	288.18	561
NAN-190	5-HT_1A-specific antagonist	>1000	1030
Dopamine		>1000	>10,000

Affinity estimates are given as K_i values in nanomolar concentrations and were determined by a computer-assisted nonlinear curve analysis (GraphPad PRISM 3.0 computer program). ^aAdapted from Angers et al. (1998); ^badapted from Barbas et al. (2002).