Figure 3. Ras and PI3K inhibition of salivary gland degradation requires TOR.

Paraffin sections 24 hours apf show that increasing the cell cycle by expression of either (A) Myc or (B) CycD with Cdk4 in the salivary gland does not prevent salivary gland degradation. Inhibition of salivary gland degradation by expression of (C) Ras^V12 in the salivary glands (circled) is ameliorated by co-expression of (D) Ras^V12 with TOR^ted. Similarly, inhibition of salivary gland degradation by expression of (E) Dp110 in the salivary glands is ameliorated by co-expression of (F) Dp110 with TOR^ted. Scale bar in (A) is 200 μm and (A–F) are the same magnification. Red boxes indicate the region of higher magnification shown in the insets for each image. Red arrows point to salivary gland fragments. Black arrowheads point to fat body that is present in the area after the salivary gland has degraded. Symbols are (b) brain, (m) muscle and (g) gut.