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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Neurobiol Dis. 2007 Aug 21;29(1):71–80. doi: 10.1016/j.nbd.2007.08.002

Figure 4.

Figure 4

Proliferation of NPCs in the brain of AD-like transgenic mice. A. Representative BrdU and LacZ staining images demonstrating that the majority of NPCs in the dentate gyrus (DG) of Bi-Tg and age-matched control pNes-Tg mice at 2, 8 and 12 months of age (m) are not co-localized. B. The total number of BrdU-positive cells in the DG (−1.70 to −2.66 from Bregma) of the Bi-Tg mice at 2, 8 and 12 months of age compared to that of the age-matched control pNes-Tg mice (* p<0.01; ** p<0.05;). C. The total number of BrdU-positive cells in the subgranular zone (SGZ) and the outer portion of the granular cell layer (oGCL) (−1.70 to −2.66 from Bregma) of the Bi-Tg mice at 2, 8 and 12 months of age compared to that of the age-matched control pNes-Tg mice (* p<0.01; ** p<0.05; ***p<0.05). D. Representative BrdU and LacZ staining images demonstrating that some of NPCs in the lateral ventricle (LV) of Bi-Tg and age-matched control pNes-Tg mice at 2, 8 and 12 months of age (m) are co-localized with BrdU, suggesting NPCs in the LV are proliferative. E. The relative BrdU staining intensity in the lateral ventricle regions of Bi-Tg mice at 2, 8 and 12 months of age (m) compared to age-matched pNes-Tg mice (*p< 0.05).