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. 1977 May 1;145(5):1169–1175. doi: 10.1084/jem.145.5.1169

The Ly phenotype of suppressor T cells arising in mice subjected to a graft-versus-host reaction

PMCID: PMC2180659  PMID: 16073

Abstract

T cells with helper and suppressor functions arising during graft- versus-host reaction (B6 vs. BDF1) have been characterized with respect to their Ly surface antigens. Helper cells were found to express the phenotype Ly 1+2- and suppressor cells the phenotype Ly 1+2+. Ly 1-2+ T cells had no suppressive effect in this system. T cells of the host did not contribute to either activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beverley P. C., Woody J., Dunkley M., Feldmann M., McKenzie I. Separation of suppressor and killer T cells by surgace phenotype. Nature. 1976 Aug 5;262(5568):495–497. doi: 10.1038/262495a0. [DOI] [PubMed] [Google Scholar]
  2. Cantor H., Boyse E. A. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J Exp Med. 1975 Jun 1;141(6):1376–1389. doi: 10.1084/jem.141.6.1376. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cantor H., Shen F. W., Boyse E. A. Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses. J Exp Med. 1976 Jun 1;143(6):1391–1340. doi: 10.1084/jem.143.6.1391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Coutinho A. The theory of the 'one nonspecific signal' model for b cell activation. Transplant Rev. 1975;23:49–65. doi: 10.1111/j.1600-065x.1975.tb00148.x. [DOI] [PubMed] [Google Scholar]
  5. Feldmann M., Beverley P. C., Dunkley M., Kontiainen S. Different Ly antigen phenotypes of in vitro induced helper and suppressor cells. Nature. 1975 Dec 18;258(5536):614–616. doi: 10.1038/258614a0. [DOI] [PubMed] [Google Scholar]
  6. Herzenberg L. A., Okumura K., Cantor H., Sato V. L., Shen F. W., Boyse E. A., Herzenberg L. A. T-cell regulation of antibody responses: demonstration of allotype-specific helper T cells and their specific removal by suppressor T cells. J Exp Med. 1976 Aug 1;144(2):330–344. doi: 10.1084/jem.144.2.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jandinski J., Cantor H., Tadakuma T., Peavy D. L., Pierce C. W. Separation of helper T cells from suppressor T cells expressing different Ly components. I. Polyclonal activation: suppressor and helper activities are inherent properties of distinct T-cell subclasses. J Exp Med. 1976 Jun 1;143(6):1382–1390. doi: 10.1084/jem.143.6.1382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kisielow P., Hirst J. A., Shiku H., Beverley P. C., Hoffman M. K., Boyse E. A., Oettgen H. F. Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse. Nature. 1975 Jan 17;253(5488):219–220. doi: 10.1038/253219a0. [DOI] [PubMed] [Google Scholar]
  9. Mishell R. I., Dutton R. W. Immunization of dissociated spleen cell cultures from normal mice. J Exp Med. 1967 Sep 1;126(3):423–442. doi: 10.1084/jem.126.3.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Möller G. Suppressive effect of graft versus host reactions on the immune response to heterologous red cells. Immunology. 1971 Apr;20(4):597–609. [PMC free article] [PubMed] [Google Scholar]
  11. Pickel K., Hoffmann M. K. Suppressor T cells arising in mice undergoing a graft-vs-host response. J Immunol. 1977 Feb;118(2):653–656. [PubMed] [Google Scholar]
  12. Shiku H., Takahashi T., Bean M. A., Old L. J., Oettgen H. F. Ly phenotype of cytotoxic T cells for syngeneic tumor. J Exp Med. 1976 Oct 1;144(4):1116–1120. doi: 10.1084/jem.144.4.1116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sjöberg O. Antigenic competition in vitro of spleen cells subjected to a graft-versus-host reaction. Immunology. 1971 Aug;21(2):351–361. [PMC free article] [PubMed] [Google Scholar]
  14. Sjöberg O. Effect of allogeneic cell interaction on the primary immune response in vitro. Cell types involved in suppression and stimulation of antibody synthesis. Clin Exp Immunol. 1972 Nov;12(3):365–375. [PMC free article] [PubMed] [Google Scholar]

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