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. 1999 Apr 27;96(9):5007–5012. doi: 10.1073/pnas.96.9.5007

Figure 1.

Figure 1

Structure of chimeric receptors. The Hu-IFN-γR1/γR1 and Hu-IFN-γR2/γR2 are the first (15) and second (16) chains of the Hu-IFN-γ receptor complex, where the NheI site was introduced in the beginning of the transmembrane domain of these receptors. The extracellular domain (EC) of either Hu-IFN-γR1 (B, hatched bars) or Hu-IFN-γR2 (A, open bars) was fused to the transmembrane and intracellular domains (IC) of different subunits of the Hu-IFN-α receptor complex (shaded bars): the Hu-IFN-αR1 (9); the Hu-IFN-αR2b (10), and the Hu-IFN-aR2c (11, 12). The FLAG epitope was introduced at the NH2 terminus of the Hu-IFN-γR2 extracellular domain. The FLγR2/αR2ct chimera has the IFN-αR2c intracellular domain prematurely terminated after Asp-315. The γR1/γR1Stat3 chimera has the Stat1α recruitment site replaced by the Stat3 recruitment site.