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Summary of the cardiac malformations observed in Bmp4 mutants of different genotypes between E15.5 and PO
| Genotype | Defects in OT | Defects in AVC |
|---|---|---|
| Bmp4loxp-lacZ/tm1 | None observed | ASD, partial AVCD |
| cTnT-Cre; Bmp4loxp-lacZ/loxp-lacZ | None observed | ASD, partial AVCD |
| cTnT-Cre; Bmp4cre;loxp-lacZ/tm1 | DORV (80%) | Complete AVCD |
(OT) Outflow tract; (AVC) atrioventricular canal; (ASD) atrial septal defect; (AVCD) AVC defect; (DORV) double outlet right ventricle.
