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. 2003 Oct 1;17(19):2436–2449. doi: 10.1101/gad.1096603

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Figure 5. — Pathological analysis of collagen-induced arthritis. (A) Serum anti-type II collagen antibody levels in syno^+/+ and syno^+/- were measured by ELISA on day 21 after the second immunization with type II collagen. Data are expressed as mean ± S.D. (1) p < 0.01; (N.S.) not significant. (B) Serum TNFα (left) and IL-1β (right) levels were measured by ELISA on day 21 after the second immunization. Data are expressed as mean ± S.D. (1) p < 0.01; (N.S.) not significant. (C) Histological arthritis score of collagen-induced arthritis in syno^+/+ and syno^+/- mice. (D) Sagittal sections of synovia from CIA-syno^+/+ and CIA-syno^+/- mice, stained with hematoxylin and eosin. (E) PCNA staining (arrows) of the synovium in CIA-syno^+/+ and CIA-syno^+/- mice. There is no statistical significance between both groups. (F) TUNEL staining (arrows) of the synovium in CIA-syno^+/+ and CIA-syno^+/- mice. (G) PCNA staining (arrows) of the synovium in Synoviolin/Hrd1-overexpressing mice. (H) TUNEL staining (arrows) of the synovium in Synoviolin/Hrd1-overexpressing mice. (I) ATF6 staining (arrows) of the synovium in syno^+/+ and syno^+/- mice after CIA. Arrows indicate positive nuclear staining of PCNA, TUNEL, or ATF6. Magnification: D-I, 400×.

Figure 5. — Pathological analysis of collagen-induced arthritis. (A) Serum anti-type II collagen antibody levels in syno^+/+ and syno^+/- were measured by ELISA on day 21 after the second immunization with type II collagen. Data are expressed as mean ± S.D. (1) p < 0.01; (N.S.) not significant. (B) Serum TNFα (left) and IL-1β (right) levels were measured by ELISA on day 21 after the second immunization. Data are expressed as mean ± S.D. (1) p < 0.01; (N.S.) not significant. (C) Histological arthritis score of collagen-induced arthritis in syno^+/+ and syno^+/- mice. (D) Sagittal sections of synovia from CIA-syno^+/+ and CIA-syno^+/- mice, stained with hematoxylin and eosin. (E) PCNA staining (arrows) of the synovium in CIA-syno^+/+ and CIA-syno^+/- mice. There is no statistical significance between both groups. (F) TUNEL staining (arrows) of the synovium in CIA-syno^+/+ and CIA-syno^+/- mice. (G) PCNA staining (arrows) of the synovium in Synoviolin/Hrd1-overexpressing mice. (H) TUNEL staining (arrows) of the synovium in Synoviolin/Hrd1-overexpressing mice. (I) ATF6 staining (arrows) of the synovium in syno^+/+ and syno^+/- mice after CIA. Arrows indicate positive nuclear staining of PCNA, TUNEL, or ATF6. Magnification: D-I, 400×.