Table 1.

Quantification or pancreatic endocrine cell content alterations in Arx-deficient mice

	Endocrine cell distribution in Arx mutant mice
Hormone-producing cells	Wild-type, Arx heterozygotes	Arx hemizygotes	Percent difference
Insulin	307 ± 35 (61%)	404 ± 23 (74%)	+31
Glucagon	143 ± 26 (28%)	0	—
Somatostatin	44 ± 14 (9%)	135 ± 28 (25%)	+207
Pancreatic polypeptide	9 ± 4 (2%)	8 ± 3 (1%)	∼0
Total cells	503 ± 79	547 ± 54	∼0

Endocrine cells were counted from immunostained sections of 2-day-old pancreas estimated to be the same size. Data are shown as the mean number ± S.E. of the mean (S.E.M.) of hormone-positive cells per section (every tenth section) from at least three independent pancreata. Percentages in brackets indicate the contribution of a particular endocrine cell-subtype to the total islet cell population. Hemizygous Arx pancreas lacks α cells, whereas β- and δ-cell content are increased 1.31- and 2.07-fold, respectively. Importantly, the total endocrine cell number is unchanged following Arx distribution