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. 1999 Apr 27;96(9):5117–5122. doi: 10.1073/pnas.96.9.5117

Figure 1.

Figure 1

(A) SSCP analysis of amplified exon 13 DNA from various patients with XP. (Lane 1) BCC from patient M.J. (Lane 2) Squamous-cell carcinoma (SCC) from patient M.J. (Lane 3) Blank—no sample. (Lane 4) BCC from patient M.H. (Lane 5) Unexposed healthy skin from patient M.H. The presence of a shifted band (arrowhead, lane 4) compared with its absence in a wild-type sample (lane 5) indicates a modified sequence (see Table 1). (B) Direct sequence analysis of amplified exon 13 DNA of a BCC from patient M.J. that did not show mobility shift by SSCP analysis (A, lane 1). The C → T transition is seen as a weak but clear band compared with the wild-type allele sequence.