Table 3.

Polymorphisms of the hptc gene

Exon/intron	Polymorphism	Effect on coding
Exon 5	A or G at 723	No change Thr-245
Intron 5	T or C 55 bp 5′ of exon 6	—
Exon 11	C or T at 1540	No change Leu-518
Exon 13	C or T at 2161	Pro/Ser at 725
Exon 13	A or G at 2187	No change Ser-733
Intron 14	G or C 8 bp 3′ of exon 14	—
Exon 19	A or G at 3313	Ser/Glu at 1,109

The hptc gene alterations characterized as polymorphisms in this study are indicated on the coding strand, written 5′ to 3′ as described by Hahn et al. (4), and the eventual modifications on amino acids are numbered as described by Johnson et al. (5).