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. 1999 Apr 27;96(9):5135–5140. doi: 10.1073/pnas.96.9.5135

Figure 3.

Figure 3

The magnitude of the CD4+ and CD8+ T cell responses in spleen (A and D) and the extent of depletion following treatment with the 2.43 mAb to CD8 (B and E) is shown for μMT → B6 (A and B) and μMT → C2D (D and E) chimeras at 21 days after i.n. infection with MHV-68. In both cases, the predominant CD4+ T cell population in mice lacking the CD8+ subset showed the activated CD44high CD62Llow phenotype (C and F, Lower Right). The μMT → B6 mice have the potential to express the MHC class II glycoproteins that target the CD4+ subset in the radiation sensitive (μMT) and radiation-resistant (B6) compartments, whereas only cells of recent hemopoietic origin (μMT) could be MHC class II+ stimulators in the μMT → C2D chimeras.