Table 1.
Treatment | Days after infection
|
||
---|---|---|---|
17 | 21 | 29 | |
Undepleted | 0.82 ± 0.17 | 1.15 ± 0.20 | 0.10 ± 0.17 |
Anti-CD4 | ND | 3.12 ± 0.48 | 2.95 ± 0.47 |
Anti-CD8 | ND | 2.68 ± 0.29 | 0.00 ± 0.00 |
Anti-CD4/CD8 | 8.00 ± 0.01 | All dead |
The μMT mice were dosed i.p. (27, 32) with the GK1.5 and/or 2.43 mAbs every second day, starting 4 days before i.n. infection with 600 pfu of MHV-68. Groups of three or four mice were sampled at different times after virus challenge, and titers are expressed as mean ± SD log10 values of lung homogenates (pfu/ml). ND, not done.