Table 2.

Effect of differential MHC class II glycoprotein expression in the radiation-resistant compartment on the control of MHV-68 infection in chimeric mice

Group	Depletion	Mortality	Virus in lung		Virus in spleen
			No.	Titer	Latent virus	Replicating virus
	Nil	2/9	2	0.30, 0.30	0.74 ± 0.81*	1.19 ± 0.49
μMT → B6	CD8	0/7	7	2.46 ± 1.03†‡	2.78 ± 0.44†§	1.28 ± 0.26‡
	CD8/IFN-γ	5/7	2	4.19 ± 0.58	4.45 ± 0.84	2.29 ± 0.57
	Nil	6/10	4	2.24 ± 0.23	3.10 ± 0.39*	1.06 ± 0.70
μMT → C2D	CD8	2/10	8	5.27 ± 1.29‡§	4.45 ± 0.54†‡	2.64 ± 0.40†‡
	CD8/IFN-γ	6/6

The chimeric mice were dosed i.p. with mAbs to CD4, CD8, and IFN-γ every second day, commencing 2 days before i.n. challenge with 600 pfu of MHV-68. Some of the mice died (mortality) before the time of sampling on day 21 after infection. No virus was detected in the lungs of 5 of 7 undepleted μMT → B6 mice, but all other lung samples were positive and evidence of both virus replication and latency was found uniformly for the spleens. The titers shown are the mean ± SD log₁₀ values for the lungs (pfu/ml) and the mean ± SD log₁₀ values for cell equivalents containing virus for the spleens. 

^*These two values were significantly different (P < 0.02). 

^†P < 0.01, compared to the Nil group. 

^‡These two values were significantly different (P < 0.02). 

^§P < 0.05, compared to the Nil group.