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. 1999 Apr 27;96(9):5159–5163. doi: 10.1073/pnas.96.9.5159

Figure 2.

Figure 2

Expression of hsp60 affects the rejection of skin allografts. (A, Left) Eα.hsp60 transgenic skin is not rejected when transplanted to wild-type NOD mice. (A, Right) Eα.hsp60 transgenic mice do not reject wild-type skin. (B, Left) The accelerated rejection (P < 0.0001) of Eα.hsp60 transgenic NOD skin (◊) compared with wild-type NOD skin (□) transplanted to BALB/c mice. (B, Right) The accelerated rejection (P < 0.038) of Eα.hsp60 transgenic male NOD skin transplanted to HY incompatible, wild-type female NOD mice. (C, Left) The delay in rejection (P = 0.004) of allogeneic C57BL/6 (H-2b) skin by Eα.hsp60 transgenic NOD mice (H-2g7). (C, Right) The delay in rejection (P = 0.001) of BALB/k (H-2k) skin by Eα.hsp60 transgenic mice. Each group contained 10–12 mice. ◊, Eα.hsp60 recipients; □, control wild-type mice. The mice used in these and other experiments in the paper were 2 months old.