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. 1999 Apr 27;96(9):5159–5163. doi: 10.1073/pnas.96.9.5159

Figure 3.

Figure 3

Spontaneous T cell proliferation of wild-type or hsp60-transgenic NOD mice to hsp60 peptides. Groups of six 2-month-old mice were tested individually for spontaneous reactivity to hsp60 peptides p278, p277, and MT-p278, and to no added peptide (control). Compared with wild-type NOD mice, the Eα.hsp60 NOD transgenics manifest a lack of spontaneous T cell reactivity to the self-hsp60 peptide p277, but their spontaneous T cell reactivity to a foreign T-cell epitope in NOD mice (18), the mycobacterial hsp60 peptide MT-p278, is not diminished. The mouse homologue of MT-p278, p278, is not a T cell epitope in NOD mice.