Figure 5.

Treatment with hsp60 peptides induces delayed rejection of skin allografts. Wild-type NOD (H-2^g7) mice were treated with various hsp60 peptides (50 μg) in IFA. Control mice were untreated (□) or were treated with IFA containing peptide p11, which is nonimmunogenic in NOD mice (♦) (26). The differences in rejection between treatment with hsp60 epitope peptides p12 (■) or p277 (▵) and the controls were significant (P < 0.0001). The experiment was repeated three times with similar results.