Table 1.
| |||
---|---|---|---|
Reactant | Product | R | Yield (%)* |
4a | 3a | m-CF3 | 62% |
4b | 3b | H | 66% |
4c | 3c | o-OCH3 | 69% |
4d | 3d | p-OCH3 | 67% |
4e | 3e | p-CH3 | 61% |
4f | 3f | p-tbutyl | 64% |
4g | 3g | o-F | 60% |
4h | 3h | p-F | 66% |
4i | 3i | 3,5-CF3 | 42% |
4j | 3j | o-OCH3, 5-F | 66% |
4k | 3k | 3,5-F | 51% |
4l | 3l | m-NO2 | 58% |
4m | 3m | m-NO2, p-CH3 | 59% |
4n | 3n | o-Cl | 59% |
Yields calculated from intermediate 2 following the one-pot Suzuki coupling and Boc deprotection