Abstract
Schistosoma mansoni schistosomula recovered from the lungs of inbred mice were shown to possess serologically detectable alloantigens on their tegumental surfaces. Using appropriate antisera and infected congenic and recombinant mice as worm donors, gene products of the K and I subregions of the major histocompatibility complex were demonstrated among these alloantigens acquired by the parasites. In contrast, other cell surface alloantigens, such as Thy 1, Ly 1, and H-Y and the serum proteins albumin, C3 and Ig, could not be detected on the surface of lung schistosomula by means of comparable techniques. In another series of experiments, schistosomula recovered from the lungs of mice and reinjected into allogeneic recipients were shown to exchange their alloantigens during an 87-h period of examination. Similarly, lung schistosomula cocultured with allogeneic lymphocytes were shown to acquire major histocompatibility complex (MHC) coded antigens from the cells. It is possible that as acquired host molecules, MHC gene products may disguise the surface of schistosome parasites thereby rendering them insusceptible to immune attack.
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Selected References
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- Clegg J. A., Smithers S. R. The effects of immune rhesus monkey serum on schistosomula of Schistosoma mansoni during cultivation in vitro. Int J Parasitol. 1972 Mar;2(1):79–98. doi: 10.1016/0020-7519(72)90036-7. [DOI] [PubMed] [Google Scholar]
- Cullen S. E., Freed J. H., Nathenson S. G. Structural and serological properties of murine Ia alloantigens. Transplant Rev. 1976;30:236–270. doi: 10.1111/j.1600-065x.1976.tb00222.x. [DOI] [PubMed] [Google Scholar]
- Dean D. A. Decreased binding of cytotoxic antibody by developing Schistosoma mansoni. Evidence for a surface change independent of host antigen adsorption and membrane turnover. J Parasitol. 1977 Jun;63(3):418–426. [PubMed] [Google Scholar]
- Dean D. A. Schistosoma mansoni: adsorption of human blood group A and B antigens by schistosomula. J Parasitol. 1974 Apr;60(2):260–263. [PubMed] [Google Scholar]
- Dean D. A., Sell K. W. Surface antigens on Schistosoma mansoni. II. Adsorption of a Forssman-like host antigen by schistosomula. Clin Exp Immunol. 1972 Dec;12(4):525–540. [PMC free article] [PubMed] [Google Scholar]
- Doherty P. C., Blanden R. V., Zinkernagel R. M. Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity. Transplant Rev. 1976;29:89–124. doi: 10.1111/j.1600-065x.1976.tb00198.x. [DOI] [PubMed] [Google Scholar]
- Goldring O. L., Clegg J. A., Smithers S. R., Terry R. J. Acquisition of human blood group antigens by Schistosoma mansoni. Clin Exp Immunol. 1976 Oct;26(1):181–187. [PMC free article] [PubMed] [Google Scholar]
- Goldring O. L., Kusel J. R., Smithers S. R. Schistosoma mansoni: origin in vitro of host-like surface antigens. Exp Parasitol. 1977 Oct;43(1):82–93. doi: 10.1016/0014-4894(77)90010-8. [DOI] [PubMed] [Google Scholar]
- Goldring O. L., Sher A., Smithers S. R., McLaren D. J. Host antigens and parasite antigens of murine Schistosoma mansoni. Trans R Soc Trop Med Hyg. 1977;71(2):144–148. doi: 10.1016/0035-9203(77)90083-9. [DOI] [PubMed] [Google Scholar]
- Lichtenberg F., Sher A., Gibbons N., Doughty B. L. Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni. Am J Pathol. 1976 Sep;84(3):479–500. [PMC free article] [PubMed] [Google Scholar]
- McKenzie I. F., Clarke A., Parish C. R. Ia antigenic specificities are oligosaccharide in nature: hapten-inhibition studies. J Exp Med. 1977 Apr 1;145(4):1039–1053. doi: 10.1084/jem.145.4.1039. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McLaren D. J., Clegg J. A., Smithers S. R. Acquisition of host antigens by young Schistosoma mansoni in mice: correlation with failure to bind antibody in vitro. Parasitology. 1975 Feb;70(1):67–75. doi: 10.1017/s0031182000048873. [DOI] [PubMed] [Google Scholar]
- Paul W. E., Benacerraf B. Functional specificity of thymus- dependent lymphocytes. Science. 1977 Mar 25;195(4284):1293–1300. doi: 10.1126/science.320663. [DOI] [PubMed] [Google Scholar]
- Schwartz B. D., Kato K., Cullen S. E., Nathenson S. G. H-2 histocompatibility alloantigens. Some biochemical properties of the molecules solubilized by NP-40 detergent. Biochemistry. 1973 May 22;12(11):2157–2164. doi: 10.1021/bi00735a023. [DOI] [PubMed] [Google Scholar]
- Sher A. Complement-dependent adherence of mast cells to schistosomula. Nature. 1976 Sep 23;263(5575):334–336. doi: 10.1038/263334a0. [DOI] [PubMed] [Google Scholar]
- Sher A. Immunity against Schistosoma mansoni in the mouse. Am J Trop Med Hyg. 1977 Nov;26(6 Pt 2):20–28. doi: 10.4269/ajtmh.1977.26.20. [DOI] [PubMed] [Google Scholar]
- Sher A., Mackenzie P., Smithers S. R. Decreased recovery of invading parasites from the lungs as a parameter of acquired immunity to schistosomiasis in the mouse. J Infect Dis. 1974 Dec;130(6):626–633. doi: 10.1093/infdis/130.6.626. [DOI] [PubMed] [Google Scholar]
- Smithers S. R., McLaren D. J., Ramalho-Pinto F. J. Immunity to schistosomes: the target. Am J Trop Med Hyg. 1977 Nov;26(6 Pt 2):11–19. doi: 10.4269/ajtmh.1977.26.11. [DOI] [PubMed] [Google Scholar]
- Smithers S. R., Terry R. J., Hockley D. J. Host antigens in schistosomiasis. Proc R Soc Lond B Biol Sci. 1969 Feb 25;171(1025):483–494. doi: 10.1098/rspb.1969.0007. [DOI] [PubMed] [Google Scholar]
- Smithers S. R., Terry R. J. The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology. 1965 Nov;55(4):695–700. doi: 10.1017/s0031182000086248. [DOI] [PubMed] [Google Scholar]
- von Lichtenberg F., Sher A., McIntyre S. A lung model of schistosome immunity in mice. Am J Pathol. 1977 Apr;87(1):105–123. [PMC free article] [PubMed] [Google Scholar]