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. 1999 May 3;145(3):619–631. doi: 10.1083/jcb.145.3.619

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Inhibition of actin reorganization or tyrosine phosphorylation prevents formation of laminin surface networks. Myotubes were preincubated with either cytochalasin, an agent that interferes with assembly and disassembly of actin filaments, or genistein, an agent that blocks tyrosine phosphorylation. Treated and untreated myotubes were incubated with 5 μg/ml laminin and evaluated for the presence of laminin surface networks after 4 h. Cytochalasin and genistein both prevented characteristic laminin surface networks from forming and disrupted laminin reorganization and clearance. Bar, 5 μm; insets are twice the magnification.