Abstract
These experiments tested whether Tc cells specific for foreign antigen (X) plus self H-2 adsorbed to macrophage monolayers displaying (a) X with allogeneic H-2; (B) self H-2 alone; (c) X plus self H-2. Specific adsorption occurred only in case (c), a result compatible with altered self and requiring further operational assumptions in dual recognition models.
Full Text
The Full Text of this article is available as a PDF (344.7 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bevan M. J., Langman R. E., Cohn M. H-2 antigen-specific cytotoxic T cells induced by concanavalin A: estimation of their relative frequency. Eur J Immunol. 1976 Mar;6(3):150–156. doi: 10.1002/eji.1830060303. [DOI] [PubMed] [Google Scholar]
- Blanden R. V., Ada G. L. A dual recognition model for cytotoxic T cells based on thymic selection of precursors with low affinity for Self H-2 antigens. Scand J Immunol. 1978 Mar;7(3):181–190. doi: 10.1111/j.1365-3083.1978.tb00442.x. [DOI] [PubMed] [Google Scholar]
- Brondz B. D., Egorov I. K., Drizlikh G. I. Private specificities of H-2K and H-2D loci as possible selective targets for effector lymphocytes in cell-mediated immunity. J Exp Med. 1975 Jan 1;141(1):11–26. doi: 10.1084/jem.141.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davidson W. F., Parish C. R. A procedure for removing red cells and dead cells from lymphoid cell suspensions. J Immunol Methods. 1975 Jun;7(2-3):291–300. doi: 10.1016/0022-1759(75)90026-5. [DOI] [PubMed] [Google Scholar]
- Doherty P. C., Blanden R. V., Zinkernagel R. M. Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity. Transplant Rev. 1976;29:89–124. doi: 10.1111/j.1600-065x.1976.tb00198.x. [DOI] [PubMed] [Google Scholar]
- Doherty P. C., Zinkernagel R. M. Specific immune lysis of paramyxovirus-infected cells by H-2-compatible thymus-derived lymphocytes. Immunology. 1976 Jul;31(1):27–32. [PMC free article] [PubMed] [Google Scholar]
- Gardner I. D., Blanden R. V. The cell-mediated immune response to ectromelia virus infection. II. Secondary response in vitro and kinetics of memory T cell production in vivo. Cell Immunol. 1976 Mar 15;22(2):283–296. doi: 10.1016/0008-8749(76)90030-7. [DOI] [PubMed] [Google Scholar]
- Gardner I. D., Bowern N. A., Blanden R. V. Cell-medicated cytotoxicity against ectromelia virus-infected target cells. III. Role of the H-2 gene complex. Eur J Immunol. 1975 Feb;5(2):122–127. doi: 10.1002/eji.1830050210. [DOI] [PubMed] [Google Scholar]
- Gardner I., Bowern N. A., Blanden R. V. Cell-mediated cytotoxicity against ectromelia virus-infected target cells. I. Specificity and kinetics. Eur J Immunol. 1974 Feb;4(2):63–67. doi: 10.1002/eji.1830040202. [DOI] [PubMed] [Google Scholar]
- Geib R., Chiang C., Klein J. Evidence for multiple clones of cytotoxic T cells responding to antigenic determinants on the same molecule. J Immunol. 1978 Jan;120(1):340–342. [PubMed] [Google Scholar]
- Janeway C. A., Wigzell H., Binz H. Two different VH gene products make up the T-cell receptors. Scand J Immunol. 1976;5(9):993–1001. doi: 10.1111/j.1365-3083.1976.tb03051.x. [DOI] [PubMed] [Google Scholar]
- Kees U., Blanden R. V. A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection. J Exp Med. 1976 Feb 1;143(2):450–455. doi: 10.1084/jem.143.2.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koszinowski U., Ertl H., Wekerle H., Thomssen R. Recognition of alterations induced by early vaccinia surface antigens and dependence of virus-specific lysis on H-2 antigen concentration on target cells. Cold Spring Harb Symp Quant Biol. 1977;41(Pt 2):529–537. doi: 10.1101/sqb.1977.041.01.061. [DOI] [PubMed] [Google Scholar]
- Langman R. E. Cell-mediated immunity and the major histocompatibility complex. Rev Physiol Biochem Pharmacol. 1978;81:1–37. doi: 10.1007/BFb0034090. [DOI] [PubMed] [Google Scholar]
- Neefe J. R., Sachs D. H. Specific elimination of cytotoxic cells. II. Reduction of cytotoxic activity by adsorption on monolayers results from removal of cytotoxic cells and not from inhibition of their activity. Cell Immunol. 1977 Mar 1;29(1):129–136. doi: 10.1016/0008-8749(77)90281-7. [DOI] [PubMed] [Google Scholar]
- Neefe J. R., Sachs D. H. Specific elimination of cytotoxic effector cells. I. Adsorptive behavior of effectors and their precursors and spleen cell monolayers. J Exp Med. 1976 Oct 1;144(4):996–1008. doi: 10.1084/jem.144.4.996. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shearer G. M., Rehn T. G., Schmitt-Verhulst A. M. Role of the murine major histocompatibility complex in the specificity of in vitro T-cell-mediated lympholysis against chemically-modified autologous lymphocytes. Transplant Rev. 1976;29:222–246. doi: 10.1111/j.1600-065x.1976.tb00203.x. [DOI] [PubMed] [Google Scholar]
- Yap K. L., Ada G. L. Cytotoxic T cells specific for influenza virus-infected target cells. Immunology. 1977 Feb;32(2):151–159. [PMC free article] [PubMed] [Google Scholar]
- Zinkernagel R. M., Callahan G. N., Althage A., Cooper S., Klein P. A., Klein J. On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition? J Exp Med. 1978 Mar 1;147(3):882–896. doi: 10.1084/jem.147.3.882. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zinkernagel R. M. H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice. J Exp Med. 1976 Feb 1;143(2):437–443. doi: 10.1084/jem.143.2.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
- von Boehmer H., Haas W., Jerne N. K. Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice. Proc Natl Acad Sci U S A. 1978 May;75(5):2439–2442. doi: 10.1073/pnas.75.5.2439. [DOI] [PMC free article] [PubMed] [Google Scholar]