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. 1999 Apr 27;96(9):5257–5262. doi: 10.1073/pnas.96.9.5257

Figure 5.

Figure 5

The complex spike and simple spike pause durations are reduced in Purkinje cells of alert Cr−/− mice. The extracellular activity of Purkinje cells was explored in vivo in 2- to 4-month-old (A and B) and 2- to 2.5-year-old (n = 3–4 per group) (C and D) mice. The complex spike duration and simple spike pause duration were reduced in Cr−/− mice. Representative recording traces for Cr+/+ (A and C) and Cr−/− (B and D) mice show start (vertical dashed line) and end (empty arrowheads) of the complex spike as well as end of the simple spike pause (filled arrowheads). For the determination of the simple spike pause duration, the complex spike was used as a trigger for the averaging of the simple spike discharge (transformed in rectangular pulses of 1 ms in duration) (lower rows). CS, complex spike; SS, simple spike. [Bars = 0.5 mV (A and B), = 1 mV (C), and = 0.3 mV (D).