Figure 3.

Distribution of dendrite curvature inside versus outside of Aβ deposits. (a) Dendrites in non-AD control cases are straight and have no significant changes in their curvature when they traverse Aβ deposits. (b) Alz-50 immunoreactive dendrites have a nearly 4-fold increase in curvature compared with dendrites from controls. There is no additional change in their curvature as they pass through Aβ deposits. (c) Alz-50-negative dendrites also have altered morphology in AD cases, but only when they traverse Aβ deposits. Dendrites have a 3-fold increase in curvature inside Aβ deposits as compared with dendrites from control cases. By contrast, there is no increase in curvature of Alz-50-negative dendrites outside of Aβ deposits as compared with dendrites from control cases.