Table 1.
COOH-terminal Consensus Sequences and Ligands for the PDZ Domains of EBP50 and E3KARP
| Sequence position | PDZ preference | Location | References | ||||
|---|---|---|---|---|---|---|---|
| −3 | −2 | −1 | 0 | ||||
| Peptide consensus | |||||||
| D | S/T | R/F/Y | L | PDZ-1 | — | Wang et al. 1998 | |
| D | S/T | W | L | PDZ-2 | — | Wang et al. 1998 | |
| D | S/T | A/R/F/L | L | PDZ-1 | — | Hall et al. 1998a | |
| Protein | |||||||
| EPI64 | D | T | Y | L | PDZ-1 | Microvillar | This study |
| CFTR | D | T | R | L | PDZ-1 | Apical | Hall et al. 1998a; Short et al. 1998; Wang et al. 1998 |
| PLC-β1 | D | T | P | L | PDZ-1 | — | Tang et al. 2000 |
| H+ATPase β1 | D | T | A | L | PDZ-1 | — | Breton et al. 2000 |
| P2YR | D | T | S | L | PDZ-1 | — | Hall et al. 1998a |
| β2AR | D | S | S | L | PDZ-1 | — | Hall et al. 1998b |
| PDGFR | D | S | F | L | PDZ-1 | — | Maudsley et al. 2000 |
| Trp4 | T | T | R | L | PDZ-1 | — | Tang et al. 2000 |
| Trp5 | T | T | R | L | PDZ-1 | — | Tang et al. 2000 |
| PLC-β2 | E | S | R | L | PDZ-1 | — | Tang et al. 2000 |
| Nadrin | S | T | A | L | PDZ-1 | — | This study |
| CANPX | L | T | E | L | PDZ-1 | — | This study |
| PLC-β3 | N | T | Q | L | PDZ-1/-2 | — | This study; Hwang et al. 2000 |
| GRK6A | P | T | R | L | PDZ-1 | — | Hall et al. 1999 |
| YAP65 | L | T | W | L | PDZ-2 | Apical | Mohler et al. 1999 |