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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Biol Psychiatry. 2007 Jun 27;63(1):86–91. doi: 10.1016/j.biopsych.2007.04.016

Figure 2.

Figure 2

ZJ43 dose response in DBA/2 mice treated with 6 mg/kg PCP. Groups of 10–15 mice were given i.p. injections of 25, 50, 100 and 150 mg/kg ZJ43 followed 10 minutes later by PCP and their stereotypic movements recorded in the open field chamber for 10 minutes. 50 mg/kg ZJ43 was the lowest dose to produce a significant reduction in the motor behavior induced by treatment with saline-PCP. All ZJ43 effects were completely reversed by the group II mGluR antagonist LY341495.