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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Biol Psychiatry. 2007 Jun 27;63(1):86–91. doi: 10.1016/j.biopsych.2007.04.016

Figure 3.

Figure 3

Adult male NIH Swiss mice respond to 1 mg/kg dizocilpine (MK-801) with a pronounced jumping behavior that is reduced by treatment 5 minutes earlier with 200 mg/kg (i.p.) ZJ43 (s-mk, n = 27; ZJ-mk, n =16). Mice injected twice with saline (n-5), ZJ43 + saline (n = 5) or LY341495 + saline (n = 5) exhibited no jumping behavior during the 30 minutes observation interval. Strikingly, pretreatment with the group II mGluR antagonist increases the effect of MK-801 nearly 3-fold (n = 25) as did pretreatment with the antagonist and the peptidase inhibitor (n = 19).