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. 2000 Jul 10;150(1):89–104. doi: 10.1083/jcb.150.1.89

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Potential location of substitutions (yeast numbering) based on the crystal structure of bovine α-GDI. The tentative location of each of the residues (Mrs6p residue numbering) mutated in this study based on their homologous residue in α-GDI (Table ) are indicated (Schalk et al. 1996). The insert region (blue) and the Rab-binding region containing SCRs 1B (yellow) and 3B (red) are highlighted at the top of GDI and form domain I. The conserved face of GDI containing SCRs 2 (green) and 3A (purple) link domain I with a second domain II, and are oriented to the front of the image (Schalk et al. 1996). Bolded residues are those that have prominent phenotype in altering REP function.