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. 2000 Jul 10;150(1):119–130. doi: 10.1083/jcb.150.1.119

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Sequence alignment of p37A with related UCHs. Ψ-Blast using default parameters (http://www.ncbi.nlm.nih.gov/blast/psiblast.cgi) was performed to search for proteins related to p37A. The identified proteins were aligned using the CLUSTAL X Multiple Sequence Alignment Program (version 1.63b; Thompson et al. 1997). UCH37 (GenBank/EMBL/DDBJ accession #AAD31528), BAP1 (GenBank/EMBL/DDBJ accession #AF045581), and p37A (GenBank/EMBL/DDBJ accession #AF145312) are more closely related to each other than to the other UCHs (AP-UCH, GenBank/EMBL/DDBJ accession #AAB52410; UCH-D, GenBank/EMBL/DDBJ accession #P35122; UCH-L1, GenBank/EMBL/DDBJ accession #P09936; UCH-L3, GenBank/EMBL/DDBJ accession #P15374; and YUH1, GenBank/EMBL/DDBJ accession #P35127). With a gap of ∼400 amino acids, the COOH-terminal region of BAP1 (residues 640–716) is again homologous to p37A and UCH37. Residues conserved among p37A, UCH37, and BAP1, as well as the other five proteins are shown in reverse type. The active site residues (denoted with arrows) are conserved in all eight proteins.